Selected publications

Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F. (2024) Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature

Nygaard, R., Graham, C.L.B., Belcher Dufrisne, M. Colburn, J.D., Pepe, J., Hydron, M.A., Corradi, S., Brown, C.M., Ashraf, K.U., Vickery, O.N., Briggs, N.S., Deering, J.J., Kloss, B., Botta, B., Clarke, O.B., Columbus, L., Dworkin, J., Stansfeld, P.J., Roper, D.I., Mancia, F. (2023) Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex. Nature Communications

Bergman, S., Cater, R.J., Plante, A., Mancia, F., Khelashvili (2023) Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A. Nature Communications

Mani, N., Nygaard, R. Mancia, F. (2022) Gone with the Wnt(less): A mechanistic perspective on the journey of Wnt. Biochem Soc Trans

Ashraf, K.U., Nygaard, R., Vickery, O.N., Erramilli, S.K., Herrera, C.M., McConville, T.H., Petrou, V.I., Giacometti, S.I., Dufrisne, M.B., Nosol, K., Zinkle, A.P., Graham, C.L.B., Loukeris, M., Kloss, B., Skorupinska-Tudek, K., Swiezewska, E., Roper, D.I., Clarke, O.B., Uhlemann, A.C., Kossiakoff, A.A., Trent, M.S., Stansfeld, P.J., Mancia, F. (2022) Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature

Cater, R.J., Chua, G.L., Erramilli, S.K., Keener, J.E., Choy, B.C., Tokarz, P., Chin, C.F., Quek, D.Q.Y., Kloss, B., Pepe, J.G., Parisi, G., Wong, B.H., Clarke, O.B., Marty, M.T., Kossiakoff, A.A., Khelashvili, G., Silver, D.L., Mancia, F. (2021) Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Nature

Loukeris, M., Sanghai, Z.A., Vendome, J., Hendrickson, W.A., Kloss, B., Mancia, F. (2021) Fine Sampling of Sequence Space for Membrane Protein Structural Biology. J. Mol. Biol.

Kim, J. Cater, R.J., Choy, B.C., Mancia, F. (2021) Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases. J. Mol. Biol.

Nygaard, R., Yu, J., Kim, J., Ross, D.R., Parisi, G., Clarke, O.B., Virshup, D.M., Mancia, F. (2021) Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. Cell

Choy B.C., Cater, R.J., Mancia, F., Pryor, E.E. Jr. (2020) A 10-year meta-analysis of membrane protein structural biology: Detergents, membrane mimetics, and structure determination techniques. Biochim Biophys Acta Biomembr.

Tan, Y.Z., Rodrigues, J., Keener, J.E., Zheng, R.B., Brunton, R., Kloss, B., Giacometti, S.I., Rosário, A.L., Zhang, L., Niederweis, M., Clarke, O.B., Lowary, T.L., Marty, M.T., Archer, M., Potter, C.A., Carragher, B. & Mancia, F. (2020) Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis. Nature Communications.

Nygaard, R., Kim, J., Mancia, F. (2020) Cryo-electron Microscopy Analysis of Small Membrane Proteins. Current Opinion of Structural Biology

Tan, Y.Z., Zhang, L., Rodrigues, J., Zheng, R.B., Giacometti, S.I., Rosário, A.L., Kloss, B., Dandy, V.P., Wei, H., Brunton, R., Raczkowski, A.M., Athayde, D., Catalão, M.J, Pimentel, M., Clarke, O.B., Lowary, T.L., Archer, M., Niederweiss, M., Potter, C.S., Carragher, B. & Mancia, F. (2020) Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria. Molecular Cell.

Dufrisne, M.B., Jorge, C.D., Timóteo, C.G., Petrou, V.I., Ashraf, K.U., Banerjee, S., Clarke, O.B., Santos, H., Mancia, F. (2020) Structural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria. Journal of Molecular Biology.

Costabile, B.K., Kim, Y.-K., Chen, Y., Clarke, O.B., Quardo, L. & Mancia, F. (2020) Sample Preparation for Structural and Functional Analyses of the STRA6 Receptor for Retinol-Binding Protein. Methods Enzymology

Kim, J., Tan, Y.Z, Wicht, K.J.,3, Erramilli, S.K., Dhingra, S.K, Okombo. J., Vendome, J., Hagenah, L.M., Giacometti, S.I., Warren, A.L, Nosol, K., Roepe, P.D, Potter, C.S., Carragher, B., Kossiakoff, A.A., Quick, M., Fidock D.A. & Mancia, F. (2019) Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature

Montemiglio, L.C., Testi, C., Cec, P.i, Falvo, E., Pitea, M., Savino, C., Arcovito, A., Peruzzi, G., Baiocco, P., Mancia, F., Alberto Boffi, des Georges, A. and Vallone, B. (2019) Cryo-EM structure of the human Ferritin-Transferrin Receptor 1 complex. Nature Communications

Assur Sanghai, Z., Liu, Q., Clarke, O.B., Belcher-Dufrisne, M., Wiriyasermkul, P., Giese, M.H., Leal Pinto, E., Kloss, B., Tabuso, S., Love, J., Punta, M., Banerjee, S., Rajashankar, K.R., Rost, B., Logothetis, D., Quick, M., Hendrickson, W.A. and Mancia, F. (2018). Structure-based analysis of CysZ-mediated cellular uptake of sulfate. Elife

Scaglione, A., Montemiglio, L.C., Parisi, G., Asteriti, I.A., Bruni, R., Cerutti, G., Testi, C., Savino, C., Mancia, F., Lavia, P. and Vallone, B. (2017). Subcellular localization of the five members of the human steroid 5α-reductase family. Biochim Open.

Chen, Y., Clarke, O.B., Kim, J., Stowe, S., Kim, Y.K., Assur, Z., Cavalier, M., Godoy-Ruiz, R., von Alpen, D.C. Manzini, C. Blaner, W.S., Frank, J., Quadro, L., Weber, D.J., Shapiro, L., Hendrickson, W.A. and Mancia, F. (2016). Structure of the STRA6 receptor for retinol uptake. Science

Petrou, V.I., Herrera, C.M., Schultz, K.M., Clarke, O.B., Vendome, J., Tomasek, D., Banerjee, S., Rajashankar, K.R., Belcher Dufrisne, M., Kloss, B., Kloppmann, E., Rost, B., Klug, C.S., Trent, M.S., Shapiro, L. and Mancia, F. (2016). Structures of aminoarabinose transferase ArnT suggest a molecular basis for resistance to polymyxins. Science

Ardiccioni, C., Clarke, O.B., Tomasek, D., Issa, H.A., von Alpen, D.C., Pond, H.L., Banerjee, S., Rajashankar, K.R., Liu, Q., Guan, Z., Li, C., Kloss, B., Bruni, R., Kloppmann, E., Rost, B., Manzini, M.C., Shapiro, L. and Mancia, F. (2016). Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. Nat. Commun.

Clarke, O.B., Tomasek, D., Jorge, C.D., Belcher Dufrisne, M., Kim, M., Banerjee, S., Rajashankar, K.R., Shapiro, L., Hendrickson, W.A., Santos, H. and Mancia, F. (2015). Structural basis for phosphatidylinositol-phosphate biosynthesis. Nat. Commun.

Zalk, R., Clarke, O.B., des Georges, A., Grassucci, R.A., Reiken, S., Mancia, F., Hendrickson, W.A., Frank, J. and Marks, A.R. (2015). Structure of a mammalian ryanodine receptor. Nature

Sciara, G., Clarke, O.B., Tomasek, D., Kloss, B., Tabuso, S., Byfield, R., Cohn, R., Banerjee, S., Rajashankar, K.R., Slavkovic, V., Graziano, J.H., Shapiro, L. and Mancia, F. (2014) Structural basis for catalysis in a CDP-alcohol phosphotransferase. Nat. Commun.

Assur, Z., Hendrickson, W.A. and Mancia, F. (2012). Tools for Co-producing Multiple Proteins in Mammalian Cells. Methods in Molecular Biology

Liu, Q., Dahmane, T., Zhang, Z., Assur, Z., Brasch, J, Shapiro, L., Mancia, F., Hendrickson, W.A. (2012) Structures from Anomalous Diffraction of Native Biological Macromolecules. Science